Karlsruhe, Germany: Available science does not provide support for the possibility of in vivo conversion of CBD into either THC or its primary metabolites, according to data published in the journal Toxics.
A team of German researchers reviewed the relevant literature on the subject. They concluded: “[T]he in vivo conversion of CBD to Δ9-THC [is] not supported by the majority of the animal studies, where neither Δ9-THC nor one of its metabolites 11-hydroxy-THC and 11-COOH-THCA were detected in blood or in brain tissues. Adding to this, neither Δ9-THC nor any of its metabolites were detected after oral CBD administration in any of the human studies.”
Authors concluded that instances of subjects testing positive on a urine drug test for THC following the consumption of commercially available CBD products are a result of the products being tainted with THC – not because CBD is transformed in vivo to THC.
Full text of the study, “Conversion of cannabidiol (CBD) into psychotropic cannabinoids including tetrahydrocannabinol (THC): A controversy in the scientific literature,” appears in Toxics. Additional information is available in the NORML fact sheet “FAQs About CBD.”
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